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Luoyang QIBR Bearing Co.,LtdCall us : +86 − −(0379)63968877 // Email us : [email protected]
Luoyang QIBR Bearing Co.,LtdCall us : +86 − −(0379)63968877 // Email us : [email protected]
2019-10-143 Singla N Warltier DC Gandhi SD et al Treatment of acute postoperative hypertension in cardiac surgery patients: an efficacy study of clevidipine assessing its postoperative antihypertensive effect in cardiac surgery-2 (ESCAPE-2) a randomized double-blind placebo-controlled trial
2017-9-15Treatment of High Blood Pressure (JNC-7 and JNC-8) classifications and guidelines are currently applicable to perioperative patients as well (James et al 2014 Chobanian et al 2003) AccordingtoJNC-7guidelinesforeval-uation and treatment of hypertensive emergencies an immediate intervention is required in cases of hypertensive emer-
The ECLIPSE Trials: Comparative Studies of Clevidipine to Nitroglycerin Sodium Nitroprusside and Nicardipine for Acute Hypertension Treatment in Cardiac Surgery Patients Anesth Analg 2008 Oct 107(4):1110-21 doi: 10 1213/ane 0b013e31818240db
2020-7-10Clevidipine is an intravenous calcium channel antagonist of the dihydropyridine class that acts primarily as a vasodilator of the arterial bed During pediatric surgeries boluses from 10 to 20 mcg/kg and infusions from 0 5 to 5 mcg/kg/min have been used for the treatment of hypertension or when controlled hypotension is required
Treatment of acute postoperative hypertension in cardiac surgery patients: an efficacy study of clevidipine assessing its postoperative antihypertensive effect in cardiac surgery-2 (ESCAPE-2) a randomized double-blind placebo-controlled trial Anesth Analg
2019-10-143 Singla N Warltier DC Gandhi SD et al Treatment of acute postoperative hypertension in cardiac surgery patients: an efficacy study of clevidipine assessing its postoperative antihypertensive effect in cardiac surgery-2 (ESCAPE-2) a randomized double-blind placebo-controlled trial
Clevidipine has been shown to be effective for the treatment of acute hypertensive emergencies as well as preoperative intraoperative and postoperative hypertension [21–23] In these scenarios its efficacy in controlling blood pressure has been shown to be greater than
2008-7-19Treatment of acute postoperative hypertension in cardiac surgery patients: an efficacy study of clevidipine assessing its postoperative antihypertensive effect in cardiac surgery-2 (ESCAPE-2) a randomized double-blind placebo-controlled trial Anesth Analg 2008 Jul 107(1):59-67 Date 07/19/2008 Pubmed ID 18635468 DOI 10 1213/ane
Clevidipine was administered as a continuous infusion to control postoperative BP in 6 patients as a continuous infusion for intraoperative control of MAP during cooling and cardiopulmonary bypass (CPB) in three patients or as a bolus dose for the treatment of hypertension during emergence from anesthesia in
Clevidipine is a racemic mixture of two enantiomers R- and S-clevidipine both of which possess equipotent antihypertensive activity 12 The racemate is a potent short-acting vascular-selective L-type dihydropyridine calcium antagonist Clevidipine is structurally related to felodipine but contains an ester linkage which results in rapid and extensive metabolism in extravascular tissues
The Evaluation of the Effect of Ultra–Short‐Acting Clevidipine in the Treatment of Patients With Severe Hypertension (VELOCITY) trial enrolled 126 patients with systolic blood pressure (SBP) 180 mm Hg for treatment with clevidipine to a patient‐specific prespecified initial target range (ITR) of SBP to be achieved within 30 minutes
2019-10-143 Singla N Warltier DC Gandhi SD et al Treatment of acute postoperative hypertension in cardiac surgery patients: an efficacy study of clevidipine assessing its postoperative antihypertensive effect in cardiac surgery-2 (ESCAPE-2) a randomized double-blind placebo-controlled trial
Clevidipine (0 5 mg/mL in 20% lipid emulsion) was initiated after insertion of an arterial line upon the occurrence of postoperative hypertension as determined by the investigator and was administered intravenously (IV) at an initial infusion rate of 0 4 μg/kg/min (non weight-based equivalent is 2 mg/h)
2019-8-26Singla N Warltier D C Gandhi S D Treatment of acute postoperative hypertension in cardiac surgery patients: An efficacy study of clevidipine assessing its postoperative antihypertensive effect in cardiac surgery-2 (ESCAPE-2) a randomized
Singla N Warltier DC Gandhi SD et al "Treatment of Acute Postoperative Hypertension in Cardiac Surgery Patients: An Efficacy Study of Clevidipine Assessing Its Postoperative Antihypertensive Effect in Cardiac Surgery-2 (ESCAPE-2) a Randomized Double- Blind Placebo-Controlled Trial " Anesth Analg 2008 107(1):59-67 [PubMed 18635468]
ESCAPE-2 Study Group Treatment of acute postoperative hypertension in cardiac surgery patients an efficacy study of clevidipine assessing its postoperative antihypertensive effect in cardiac surgery-2 (ESCAPE-2) a randomized double-blind placebo-controlled trial Anesth Analg 107 59–67 doi: 10 1213/ane 0b013e3181732e53
2020-5-2Clevidipine is an intravenous (IV) dihydropyridine calcium-channel blocker (CCB) that is approved for the reduction of blood pressure (BP) when oral therapy is not feasible or not desirable Clevidipine is effective at reducing BP in the emergency room (ER) intensive care unit (ICU) and in the pre- peri- and postoperative settings
2012-12-21Treatment of Hypertension Assessing Safety Events (Eclipse) trial prospectively evaluated outcomes in1512 cardiac surgical patients that required treatment for APH In this analysis the clevidipine cohort was found to have a significantly lower mortality rate as compared to the nitroprusside group Clevidipine was also
Clevidipine (Cleviprex™) a late-generation dihydropyridine calcium channel antagonist available as a lipid emulsion for intravenous infusion is approved in the US for the reduction of blood pressure (BP) when oral therapy is not feasible or desirable Intravenous clevidipine is effective in the treatment of both acute preoperative and postoperative hypertension in adult cardiac surgery
Clevidipine does result in a modest increase in heart rate from baseline as has been shown with other IV CCB agents Heart rate increases within the first 30 minutes of administration but this appears to decrease back to baseline 8 The drug has been shown to be well tolerated without an increase in adverse side effects compared with placebo
2020-7-17Clevidipine is a dihydropyridine L-type calcium channel blocker highly selective for vascular as opposed to myocardial smooth muscle and therefore has little or no effect on myocardial contractility or cardiac conduction It reduces mean arterial blood pressure by decreasing systemic vascular resistance Clevidipine does not reduce cardiac filling pressure () confirming lack of effects on
Treatment of acute postoperative hypertension in cardiac surgery patients: an efficacy study of clevidipine assessing its postoperative antihypertensive effect in cardiac surgery-2 (ESCAPE-2) a randomized double-blind placebo-controlled trial Anesth Analg
The primary objective was to establish the safety of clevidipine in the treatment of perioperative hypertension as assessed by comparing the incidences of death stroke MI and renal dysfunction in the clevidipine and nitroglycerin treatment groups from the initiation of study drug infusion through postoperative Day 30
2016-3-28Background Clevidipine is an ultrashort-acting drug for rapid reduction of blood pressure by selectively acting on the L-type Ca2+ channels on arteriolar smooth muscle The drug's ultrashort action in reducing the blood pressure is due to its rapid hydrolysis by blood and extravascular tissue esterases which does not depend on hepato-renal metabolism and excretion
2017-10-17Clevidipine is a short-acting intravenous calcium chan-nel antagonist of the dihydropyridine class Rapid meta-bolism by blood and tissue esterases results in a half-life of 1-3 minutes We present anecdotal experience with the use of clevidipine to provide perioperative BP con-trol in a 2-year-old child with aortic coarctation Options
2010-1-1Eur J Anaesthesiol 2003 20:69703 Singla N Warltier DC Gandhi SD et al for the ESCAPE-2 Study Group Treatment of acute postoperative hypertension in cardiac surgery patients: An efficacy study of clevidipine assessing its postoperative antihypertensive effect in cardiac surgery-2 (ESCAPE-2) a randomized double39 40 41 42
ESCAPE-2 Study Group Treatment of acute postoperative hypertension in cardiac surgery patients an efficacy study of clevidipine assessing its postoperative antihypertensive effect in cardiac surgery-2 (ESCAPE-2) a randomized double-blind placebo-controlled trial Anesth Analg 107 59–67 doi: 10 1213/ane 0b013e3181732e53
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